Guidelines for Children With Peanut Allergy.
The number of children with peanut allergy has increased dramatically over the past 20 years. Parents may be particularly concerned about peanut allergy because most food-related serious allergic reactions, such as anaphylaxis, a severe allergic reaction that includes breathing difficulties as well as fatal allergic reactions, are associated with peanuts. Because peanut allergy is common and can be quite serious, many parents want guidelines for how to best prevent allergies to peanuts. Many research studies over the past 20 years have focused on peanut allergy and how best to prevent it. This research has been translated into guidelines for families that are mostly focused on what time in a child’s life is safest to introduce peanuts into the diet. With new research emerging, these guidelines have been updated to represent the best available evidence from research. An article in this month’s JAMA Pediatrics reviews these guidelines and the research studies that informed the guidelines.
Food Targeting: Geographical origin determination of hazelnuts (Corylus avellana) by LC-QqQ-MS/MS based targeted metabolomics application.
A targeted metabolomics LC-ESI-QqQ-MS application for geographical origin discrimination based on 20 non-polar key metabolites was developed, validated according to accepted guidelines and used for quantitation via stable isotope labeled internal standards in 202 raw authentic hazelnut samples from six countries (Turkey, Italy, Georgia, Spain, France and Germany) out of harvest years 2014 and 2015. Multivariate statistics were used for detection of significant variations in metabolite levels between countries and moreover, a prediction model using support vector machine classification (SVM) was calculated yielding 100% training accuracy and 97% cross-validation accuracy which was subsequently applied to 55 hazelnut samples for confectionary industry gaining up to 80% correct classifications compared to declared origin. The present method demonstrates the great suitability for targeted metabolomics applications in geographical origin determination of hazelnuts and their applicability in routine analytics.